请帮忙翻译关于系统生物学的文献,谢谢
来源:百度知道 编辑:UC知道 时间:2024/08/23 22:54:14
Though the Waddington and von Bertalanffy programs have not been confirmed in the typical accomplishments and representations in molecular biology in general, and molecular genetics in particular, there are interesting advances that fall between those searches for broad theories couched in mathematically precise differential equation form, and the narrow classes of mechanisms, usually described in qualitative multilevel causal language, that constitute the vast majority of current biomedical explainers. In traditional population genetics, one important exception is the ability to develop a powerful axiomatization of the subject that does bear strong analogies to equation based theories of physics. (For a detailed example see the Jacquard axiomatization of population genetics summarized in Schaffner (1993), Chapter 8.)
There are several other theories that are equation-based which can be identified in contemporary biomedicine; and in the remainder of this paper I discuss two
There are several other theories that are equation-based which can be identified in contemporary biomedicine; and in the remainder of this paper I discuss two
朋友,追加点分如何?
虽然Waddington和冯Bertalanffy节目在分子生物学和分子遗传学的典型的成就和表示法未一般来说,被证实特别是,有下跌在那些查寻之间以数学上精确微分方程形式横卧的宽广的理论的有趣的前进和在定性多重原因语言,通常描述的机制狭窄的类,构成绝大多数的当前生物医学的解说员。 在传统人口遗传学,一个重要例外是能力开发负担强的比喻对等式物理的基于理论主题的强有力的公理化。 (为详细例子看人口遗传学(1993),第8.章)的提花织物公理化在Schaffner总结的
有等式根据在当代生物医学方面可以被辨认的几种其他理论; 并且在本文剩下的人我详细谈论二这些。 我的意图是这些可能透露非常一般和定量原则在生物和医学可以被申请卓有成效地的一些重要方式。 他们也透露这种局限针对物理的方法对生物和数学模型工作那些区域的比较,并且在什么点它开始失效可以表明方式系统生物学在这个出生区域可能接近理论、模型和等式的问题。
我从Hodgkin-Huxley巨大的鱿鱼模型的发展的一个简要的帐户将开始我的讨论动作电位的,惊人的成就Hodgkin和Huxley在1963年在生理方面分享诺贝尔奖或医学。 其中一本神经科学(Kandel当前标准课本等2000)阐明,在它的出版物以后的50年, Hodgkin- Huxley模型在神经系统的科学并肩作战象最成功的定量计算模型,如果不是所有biology的`(p. 156) .1