英语翻译：他发生了什么事？

What's happened to him?
What's going on with him?
What the hell is going on with him? (他TMD怎么了,比较随便)
What's the matter with him?
What's wrong with him?
Anything wrong with him today?
What's his problem?
What's the case on him?
Did he encounter anything?
Is he in the trouble?

What has happened to him？

What's wrong with him?
What's up with him?
What's the matter with him?

What happened to him?