请问谁知道拓扑替康的LD50是多少啊？急~~~

On a q4dx4 schedule, the maximum tolerated dose (MTD) was 12.5 mg/kg per administration, which caused marked weight loss and lethality in approximately 5% of the tumor-bearing mice

我最近也在找这个，我找的是腹腔注射的。没有文献明确标明ld50具体值，但是这个文献还是很有用的，可参考这个