请问这两种药物:倍他罗定(Betaprodine),贝齐米特(Bezitramide)

来源:百度知道 编辑:UC知道 时间:2024/07/04 18:18:45
国外上市年份,用途,合成方法,使用剂型,研究情况,受限条律。有厉害的药师或学者吗?

贝齐米特Bezitramide

CAS number:15301-48-1
PubChem:61791
Formula:C31H32N4O2
Mol. Mass:492.612 g/mol
Routes:Oral
Bezitramide is a narcotic analgesic. Bezitramide itself is a prodrug which is readily hydrolyzed in the gastrointestinal tract to its main metabolite, despropionyl-bezitramide. Bezitramide was discovered at Janssen Pharmaceutica in 1961. It is most commonly marketed under the trade name Burgodin®.
The drug was pulled from the shelves in the Netherlands in 2004 after fatal overdose cases, including one where a five year old child took one tablet from his mother's purse, ate it, and promptly died.
Bezitramide is regulated much the same as morphine in all known jurisdictions and is, surprisingly, a Schedule II rather than Schedule I narcotic under the United States' Controlled Substances Act of 1970. However, it has to this point never been marketed in the United States.
Other drugs which are legal for medical use in t