despite= however吗

首先，我假设这个 however 是表达转接的意思。

虽然 despite 和 however 都是用来表达转接的意思，但是用法不一样。

意思：
despite 尽管、不管、任凭 (preposition)
however 但是、不过、然而 (adverb)

用法：
... despite + noun phrase
The game continued despite the rain.
尽管下起雨来，比赛仍然继续。

... however, + complete sentense structure
The book is expensive; however, it's worth it.
这本书很贵，但是它有那个价值。

正宗的文法是不允许以 however 开头的。但是，这个规定已经被大部分人无视。

no
despite= in spite of,although

前者是指除了...，后者是指无论怎样。