蛋白质和核酸变性的主要区别，有那位高手能系统的回答一下？

蛋白质变性：
溶解度减小（因为本来外面的亲水基团可能会被隐藏，而本来疏水的在里面的会出来）。粘度增加（因为由球状变为松散），空间结构改变，生物活性丧失，易被蛋白酶水解

核酸变性
生物学活性丧失，粘度减小（由线状变为团状），增色效应（因为能引起紫外吸收的碱基本来在里面，现在因为变性暴露出来），

如果说他们主要区别的话，应该就是形状，一个轴径比变大，而核酸则由轴径比大变为小。

Denaturation of Proteins:
http://www.elmhurst.edu/~chm/vchembook/568denaturation.html

The denaturation of nucleic acids such as DNA due to high temperatures, is the separation of a double strand into two single strands, which occurs when the hydrogen bonds between the strands are broken. This may occur during polymerase chain reaction. Nucleic acid strands realign when "normal" conditions are restored during annealing. If the conditions are restored too quickly, the nucleic acid strands may realign imperfectly.